Comparison of Surgery with Definitive Chemoradiotherapy for Potentially Resectable Esophageal Cancer: a Propensity-Score Analysis

Definitive Chemoradiation for Resectable Esophageal Cancer

The salvage operation for esophageal cancer is one of the most interesting topics today among Japanese doctors treating this form of malignant tumor. This topic has been selected as the focus of symposia and panel discussions at many annual meetings of surgical-, esophageal-, or digestive-disease–related societies in Japan. In parallel, definitive chemoradiation therapy has recently shown progr...

Neoadjuvant chemoradiotherapy for resectable esophageal carcinoma: a meta-analysis.

AIM To compare neoadjuvant chemoradiotherapy and surgery with surgery alone for resectable esophageal carcinoma. METHODS We used MEDLINE and EMBASE databases to identify eligible studies and manual searches were done to ensure no studies were missed. Trial validity assessment was performed and a trial quality score was assigned. RESULTS Eleven randomized controlled trials (RCTs) including 1...

Definitive Chemo-Radiotherapy for Resectable Esophageal Cancer — Unresolved Problems Remain

Induction chemotherapy improved outcomes of patients with resectable esophageal cancer who received chemoradiotherapy followed by surgery.

PURPOSE To investigate the effect of induction chemotherapy (CHT) before trimodality therapy on the outcome of patients with resectable cancer of the esophagus. METHODS AND MATERIALS This retrospective study included 81 consecutive patients with resectable cancer of the esophagus who received neoadjuvant chemoradiotherapy followed by esophagectomy between January 1990 and December 1998 (inclu...

Surgery for resectable esophageal cancer in Japan.

In Japan over 10,000 new cases of esophageal cancer and a little less than 10,000 deaths occur annually. Carcinoma of the esophagus occurs six times more frequently in males than females, and is the sixth most common carcinoma in males. Although adenocarcinoma is the most common form (more than 50%) in North America and many western European countries, approximately 90% of esophageal carcinoma ...